Open Access Data
This platform provides researchers with integrated multi-omics resources and comprehensive analytical tools for Alzheimer’s disease, enabling transparent, reproducible, and data-driven biomedical research.
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An integrated central-peripheral landscape integrating single-cell transcriptomic and proteomic profiles across the full Alzheimer's disease continuum.
Explore the studyFollow the proposed molecular signaling trajectory from peripheral blood across the blood-brain barrier to cerebrospinal fluid and Alzheimer's disease-related brain pathology.
Select a stage indicator to jump directly to that point in the animation.
A continuous animation shows blood cells moving through a vessel, a vascular cell releasing signaling particles, the particles crossing the blood-brain barrier and entering a purple cell in cerebrospinal fluid. The purple cell produces and releases a new particle, which then binds to a receptor on a separate green cell. A brain region beyond the cerebrospinal fluid contains amyloid-beta deposition, a neuron, and tau pathology.
Brief
The study cohort comprised 343 Chinese participants, including cognitively normal (CN) controls, as well as age- and sex-matched individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. Participants were further stratified by amyloid-beta (Aβ) status. CN individuals were classified as preclinical AD (with abnormal Aβ levels) and CN A− (with normal Aβ levels). Likewise, MCI participants were classified as MCI due to AD (Aβ-positive) or MCI due to non-AD (Aβ-negative), and dementia cases as dementia due to AD (Aβ-positive) or dementia due to non-AD (Aβ-negative). Subjects classified as preclinical AD, MCI due to AD, or dementia due to AD were collectively referred to as biologically defined AD and considered to fall within the AD continuum. Subjects classified as MCI due to non-AD or dementia due to non-AD are all categorized as non-AD.
This platform provides researchers with integrated multi-omics resources and comprehensive analytical tools for Alzheimer’s disease, enabling transparent, reproducible, and data-driven biomedical research.
Central (cerebrospinal fluid [CSF]) and peripheral (blood) single-cell RNA expression landscapes and cell type clustering.
Central (CSF) and peripheral (blood) proteins differentially expressed across the full Alzheimer’s disease continuum. All individuals with available single-cell transcriptomic data also underwent corresponding CSF or blood proteomic profiling.
Data exploration
Move directly from the study overview into interactive, modality-specific analysis.
Interrogate central and peripheral single-cell landscapes, inspect cell clusters, and compare gene expression across the AD continuum.
Compare differentially expressed CSF and blood proteins across clinical stages and biologically defined diagnoses.